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KMID : 0604520110370010043
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 1 p.43 ~ p.53
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Optimization of Nanoencapsulation Process for Azelaic Acid-Milk Nano Powder and Acne Nanocosmetics
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Kim Dong-Myong
Choi Ji-eun
Kim Duck-hoon
Lee Jun-tack
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Abstract
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The conditions in fluid-bed processor for nanoencapsulation of azelaic acid-milk nano powder for acne nanocosmetics were optimized by response surface methodology (RSM). The maximum value of yield was 70.97 %. The yield was appreciably influenced by inlet air temperature, atomizing pressure, and feeding speed. The particle size increased with an increase in the feeding speed and a decrease in the atomizing pressure. The elution rate in saline solutions was appreciably influenced by inlet air temperature and atomizing pressure. The moisture content increased with higher atomizing pressure, which was demonstrated to be similar to the nanoencapsulation characteristics related to water activity. The Hunter’s L and b values increased with an increase in the inlet air temperature. The optimum conditions estimated by RSM for the maximized values of yield, moisture content, particle size and elution rate in skin suitability were of inlet air temperature, 0.6 ~ 0.8 mL/min feeding speed and 1.8 ~ 2.0 kg/ of atomizing pressure, respectively. These estimated values were in agreement with those measured by real experiments.
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KEYWORD
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acne, nanoencapsulation, azelaic acid-milk mixture, response surface methodology (RSM), fluid-bed processor
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